Enzymatic and Toxicological Analysis of Vranaharin Ayurvedic Oil: An Experimental Study from a Clinical Perspective for Topical Applications on Necrotic Wounds

Vranaharin, an ayurvedic oil manufactured by MMCA Remedies Pharmaceuticals, Karnataka, India, is a red-colored drug, prepared from several traditionally used plant ingredients and in postoperative dressings, bedsores, burns, cuts, wounds, diabetic ulcers, abscesses, skin infections, nail fungus, herpes so on. This research aims to investigate Vranaharin oil, understand its side-effects such as antioxidant enzymes alteration the cerebral cortex of brain liver developing chick embryos, pathological effect/antimicrobial nature, ability hemolytic activity. study designed give overall toxicological analysis selected drug. The which for topical applications necrotic wounds observed cause angioneogenesis wound bed within short span application. has been investigated first time assess systemic effect local application terms possible genotoxicity embryonic toxicity. concludes that can be effectively applied over necrotized period long-term needs further investigated. Setting maximum dose standardized it caused notable fluctuations enzyme equilibrium variations superoxide dismutase, catalase, glutathione peroxidase glutathione- S-transferases levels when higher concentrations were embryos. Its highly recommended, especially necrotizing due excellent antioxidant, antimicrobial potential. angiogenic potential avascular very interesting phenomenon being our laboratory.